Browsing by Author "Pérez, Edwin G."

Now showing items 1-10 of 10

    • Alkaloids from the Genus Duguetia 
      Pérez, Edwin G.; Cassels Niven, Bruce (Elsevier, 2010)
    • Aporphine metho salts as neuronal nicotinic acetylcholine receptor blockers 
      Iturriaga-Vásquez, Patricio; Pérez, Edwin G.; Slater, E. Yvonne; Bermúdez, Isabel; Cassels Niven, Bruce (2007)
      (S)-Aporphine metho salts with the 1,2,9, 10 oxygenation pattern displaced radioligands from recombinant human 0 and alpha 4 beta 2 neuronal nicotinic acetylcholine receptors (nAChR) at low micromolar concentrations. The ...
    • A convenient, renewable source of the anxiolytic proaporphine alkaloid glaziovine: Duguetia vallicola leaves 
      Pérez, Edwin G.; Sáez, Jairo; Cassels Niven, Bruce (SOCIEDAD CHILENA DE QUIMICA, 2005-09)
      The leaves of Duguetia vallicola, a fairly common, large evergreen tree from the coastal regions of Panama, Colombia and Venezuela, contain (6aS)-glaziovine (1) as a major constituent. The abundance and renewable character ...
    • Cytisine: a natural product lead for the development of drugs acting at nicotinic acetylcholine receptors 
      Pérez, Edwin G.; Méndez Gálvez, Carolina; Cassels Niven, Bruce (2012)
      This review covers classical and modern structural modifications of the alkaloid, the more recent (since 2007) syntheses of cytisine and analogues, and the pharmacology of these compounds, with emphasis on their interactions ...
    • Further mulinane diterpenoids from Azorella compacta 
      Areche Medina, Carlos; Rojas-Álvarez, Francisca; Campos-Briones, Carolina; Lima, Carlos; Pérez, Edwin G.; Sepúlveda, Beatriz (Royal Pharmaceutical Society, 2013-04-11)
      The chemical study of a dichloromethane extract from Azorella compacta was directed to the isolation of characteristic mulinane and azorellane diterpenoids in order to determine their gastroprotective activity. Methods ...
    • Methylpiperidinium Iodides as novel antagonists for alpha 7 nicotinic acetylcholine receptors 
      López Villa, Jhon; García Colunga, Jesús; Pérez, Edwin G.; Fierro, Angélica (Frontiers Media, 2018)
      The alpha 7 nicotinic acetylcholine receptor (nAChR) is expressed in neuronal and non-neuronal cells and is involved in several physiopathological processes, and is thus an important drug target. We have designed and ...
    • Molecular modeling of the a9a10 nicotinic acetylcholine receptor subtype 
      Pérez, Edwin G.; Cassels Niven, Bruce; Zapata Torres, Gerald Amilcar (Elsevier Ltd., 2008-10-25)
      This study reports the comparative molecular modeling, docking and dynamic simulations of human a9a10 nicotinic acetylcholine receptors complexed with acetylcholine, nicotine and a-conotoxin RgIA, using as templates the ...
    • Synthesis and antiplasmodial activity of some 1-azabenzanthrone derivatives 
      Castro Castillo, Vicente; Suárez Rozas, Cristian; Pabón, Adriana; Pérez, Edwin G.; Cassels Niven, Bruce; Blair, Silvia (Elsevier, 2013)
      Some synthetic 1-azabenzanthrones (7H-dibenzo[de,h]quinolin-7-ones) are weakly to moderately cytotoxic, suggesting that they might also show antiparasitic activity. We have now tested a small collection of these compounds ...
    • The development of a fluorescence turn-on sensor for cysteine, glutathione and other biothiols. A kinetic study 
      García Beltrán, Olimpo; Mena, Natalia P.; Pérez, Edwin G.; Cassels Niven, Bruce; Núñez González, Marco; Werlinger, Francisca; Zavala, Daniel; Aliaga, Margarita E.; Pavez, Paulina (Elsevier Ltd., 2011-10-06)
      Two fluorescence probes for the detection of cysteine (Cys), glutathione (GSH) and other biothiols, such as homocysteine (Hcy) and cysteinyl-glycine (Cys-Gly), were developed. These molecular probes are coumarin-based ...
    • Why is quercetin a better antioxidant than taxifolin? Theoretical study of mechanisms involving activated forms 
      Osorio, Edison; Pérez, Edwin G.; Areche Medina, Carlos; Ruiz, Lina María; Cassels Niven, Bruce; Florez, Elizabeth; Tiznado, William (Springer, 2013)
      The stronger antioxidant capacity of the flavonoid quercetin (Q) compared with taxifolin (dihydroquercetin, T) has been the subject of previous experimental and theoretical studies. Theoretical work has focused on the ...